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  • HIV-1 infected children benefit greatly from combination therapy

    Combination therapy including protease inhibitors has been available since 1996 for adults with HIV-1 infection. The therapy has slowed the progression of HIV-1 and drastically reduced the rate of mortality…

  • Immune system discovery may lead to preventive therapy for diabetes

    The job of cells known as iNKT cells is to regulate the immune system’s response to infections and other disorders, ensuring that only diseased tissue, not healthy tissue, is targeted…

  • No innocent bystanders

    When cancer cells begin to do their destructive work, they have accomplices — normal cells that help nourish the cancerous ones. As Jack Lawler, Harvard Medical School associate professor of…

  • Cell protein potently blocks enzyme linked to cancer

    The ends of chromosomes in normal cells eventually unravel, causing the cells to die. This does not happen in cancer cells, however. Cancer cells use an enzyme named telomerase to…

  • Dopamine may play dual role in Parkinson’s disease

    According to the Parkinson’s Disease Foundation, “Parkinson’s disease (PD) is a disorder of the central nervous system that affects between one and one-and-a-half million Americans. Because it is not contagious…

  • “Heart of glass” may be more than just a metaphor

    Jeffrey Fredberg is a professor of bioengineering and physiology at the Harvard School of Public Health. His primary research interest is asthma. Fredberg was intrigued by the plasticity of the…

  • WHO report reviews world mental health care

    Since the mid-1970s, World Health Organization policies have encouraged integrating mental health services into primary care settings. But no one knows what, if anything, might be working to help those…

  • How does the brain reinvent itself?

    In order for us to use our minds for memory, for learning, and so forth, our brains must continually reinvent themselves. How do they do it? A Harvard Medical School…

  • Anthrax toxin receptor discovered

    The first point of contact between anthrax toxin that invades the body and the cells that the toxin will eventually destroy is a protein, known as a “docking” protein or…

  • Cognition unaffected by marijuana use

    Harrison Pope, a Harvard professor of psychiatry, and his colleagues at McLean Hospital, a Harvard-affiliated psychiatric facility in Belmont, Mass., investigated the long-term cognitive effects of smoking marijuana. They recruited…

  • Cardiovascular risks seen from marathon running

    Researchers analyzed the blood of marathon runners less than 24 hours after they had finished a race. They found abnormally high levels of inflammatory and clotting factors of the kind…

  • Anthrax immunity gene found in mice

    Anthrax is an often fatal disease that is caused by a bacterium. It has been considered a prime biological weapon in the arsenal of terrorists since attacks in the United…

  • A strategy to neutralize anthrax toxin in the body

    A Harvard Medical School research team has developed a strategy to neutralize anthrax toxin in the body. So far they have tried the treatment in rats. Normally, rats die within…

  • Researchers identify genes that trigger depression

    A substance known as CREB controls gene expression in the brain. It also appears to be active in mood disorders. A group of Harvard researchers at McLean Hospital in Belmont,…

  • Study shows strong public interest in genetic testing for Alzheimer’s disease

    A genetic test to determine a person’s chance of getting Alzheimer’s disease is still hypothetical. But scientists are getting closer and closer to being able to determine who is likely…

  • One-tenth of medical residents feel unprepared

    Findings from a study suggest that gaps exist in the preparedness of physicians to manage the full range of patients, procedures and problems they may encounter. A surprising one in…

  • Sorting good eggs from bad ones

    An oocyte is an immature egg cell in the ovaries. Before a woman is born, her ovaries will contain about five million eggs. At birth, about three million of those…

  • Cell death in eggs traced to smoking

    A woman is born with just so many egg cells, called oocytes. When she begins ovulating, she has about 400. Even though that may seem like a lot, considering the…

  • Common aspirin reveals mechanism of insulin resistance

    In 1876, a German professor described a treatment that led to rapid improvement in two men who were suffering from what doctors now recognize as classic type 2 diabetes. In…

  • Resistance to antibodies is reversed

    It’s a frightening — and increasingly common — problem. A patient seeks treatment for a particular ailment in a hospital and develops an entirely different disease: a bacterial infection that…

  • Researchers discover new type of cancer

    A team led by a Harvard researcher has identified a new type of cancer that primarily affects young girls. Sara Vargas, an instructor in pathology at Harvard Medical School and…

  • Harvard scientists identify chromosome location of genes associated with long life

    Scientists have long thought of aging as a complex process affected by perhaps a thousand genes. So a recent discovery by Harvard scientists that a gene or genes located on…

  • Nutrition book author Willett rebuilds USDA food pyramid

    For more than 20 years researchers at Harvard and elsewhere have been looking at the long-term health effects of eating certain types of foods. These researchers now have a good…

  • Drug hits new molecular target in mice

    When doctors diagnose and plan treatment for breast cancers they look for various indicators of how aggressive they are and what treatments will work best. Two-thirds of breast tumors are…

  • Study shows obesity can increase risk of pancreatic cancer

    Each year almost 30,000 people in the United States are diagnosed with pancreatic cancer. About the same number of people are killed by it. Pancreatic cancer is the fifth-leading cause…

  • Snack foods may increase risk of age-related sight loss

    Macular degeneration results from the malfunctioning or loss of function of photo-sensitive cells in the retina. According to the Macular Degeneration Foundation, more than 13 million people in the United…

  • Amniotic cells may be source of new tissue

    Babies born with congenital defects often require surgery. Surgeons face a problem, however — in adults, tissue for repair is borrowed from other areas of the body, but babies don’t…

  • Inflammatory villain turns do-gooder

    Many drugs try to tame inflammation by inhibiting molecular events occurring at the beginning of the body’s own immune response. But that may thwart the body’s attempt to heal. A…

  • Walking rhythm offers gait-way to reduce falls

    Over the past 10 years, Jeffrey Hausdorff has studied thousands of steps from hundreds of feet. The Harvard Medical School assistant professor says that complex patterns hidden in an ordinary…

  • Will vaccine defense help polish off tooth decay?

    The key to preventing cavities in teeth lies in controlling an acid-secreting bacterium known as Streptococcus mutans that lives in the mouth. Researchers at the Harvard School of Dental Medicine…