Health
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Lin Test
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Gender-affirming care is rare, study says
Fewer than 1 in 1,000 transgender youth receive hormones or puberty blockers
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Nature offers novel approach to oral wound care
Slug’s sticky mucus inspiration behind adhesive hydrogel that can seal wounds in wet environment
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Time for a rethink of colonoscopy guidelines?
Change informed by new findings would help specialists focus on those most at risk, researcher says
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Should pharmacists be moral gatekeepers?
‘The problem is not opioids,’ says author of ‘Policing Patients’ — it’s overdose, pain
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The deadly habit we can’t quite kick
Actions by tobacco companies worry researcher even amid ‘dramatic decrease’ in smoking among young Americans
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Understanding Ebola
Though the threat to the U.S. population from the Ebola outbreak in West Africa is low, the need in epidemic countries is great, says Michael VanRooyen, director of the Harvard Humanitarian Initiative.
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Drug delivery system prevents transplant rejection
In pre-clinical studies conducted by the researchers, a one-time, local injection of the hydrogel-drug combo prevented graft rejection for more than 100 days. This compared with 35.5 days for recipients receiving only tacrolimus, and 11 days for recipients without treatment or only receiving hydrogel.
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Enemy of ash
The Gazette spoke with Arboretum officials about the recent arrival of the emerald ash borer.
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Neurons at work
Using genetic tools to implant genes that produce fluorescent proteins in the DNA of transparent C. elegans worms, Harvard scientists have been able to shed light on neuron-specific “alternative splicing,” a process that allows a single gene to produce many different proteins.
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Progress against ALS
Studies begun by Harvard Stem Cell Institute scientists eight years ago have led to a report that may be a major step in developing treatments for amyotrophic lateral sclerosis, or Lou Gehrig’s disease.
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Viral load as an anti-AIDS hammer
Harvard researchers have joined with counterparts in the U.S. and Botswana governments to conduct a major evaluation of AIDS treatment targeted specifically to reduce infectivity.
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New hope for ‘bubble boy’ disease
Children born with so-called “bubble boy” disease have the best chance of survival if they undergo a hematopoietic stem cell transplant as soon after birth as possible, according to a detailed analysis of 10 years of outcome data by researchers at the Harvard-affiliated Dana-Farber/Boston Children’s Cancer and Blood Disorders Center.
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Help for halting autism symptoms
A new study shows that boosting inhibitory neurotransmission early in brain development can help reverse deficits in inhibitory circuit maturation that are associated with autism.
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New treatment for depression shows immediate results
In a study at Harvard-affiliated McLean Hospital, individuals with major depressive disorder or bipolar disorder who received low-field magnetic stimulation (LFMS) showed immediate and substantial mood improvement.
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Cheese-based research
Bauer Fellow Rachel Dutton has identified three general types of microbial communities that live on cheese, opening the door to using each as a “model” community for the study of whether and how various microbes and fungi compete or cooperate as they form communities, as well as what molecules and mechanisms are involved in the process.
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‘Broken genes’ for a broken system
To David Altshuler, the recent discovery of a genetic mutation that protects against type 2 diabetes offers hope in fighting more than just diabetes. It also illustrates how using the…
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Untangling spider webs
The largest-ever phylogenetic spider study shows that, contrary to popular opinion, the two groups of spiders that weave orb-shaped webs do not share a single origin.
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$650M gift to Broad seeks to propel psychiatric research
Philanthropist Ted Stanley announced plans to donate $650 million to the Broad Institute of Harvard and MIT to foster research into psychiatric diseases, whose biological causes, long a mystery, scientists have begun to tease out in recent years.
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Researchers shed new light on schizophrenia
Harvard-affiliated researchers joined an international team to identify more than 100 locations in the human genome associated with the risk of developing schizophrenia in what is the largest genomic study published on any psychiatric disorder to date.
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Viewing how neurons work
A new technique for observing neural activity will allow scientists to stimulate neurons and observe their firing pattern in real time. Tracing those neural pathways can help researchers answer questions about how neural signals propagate, and could one day allow doctors to design individualized treatments for a host of disorders.
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Sizing up bacteria
A new theoretical framework outlined by a Harvard scientist could help solve the mystery of how bacterial cells coordinate processes that are critical to cellular division, such as DNA replication, and how bacteria know when to divide.
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Antibody halts cancer-related wasting condition
New research raises the prospect of more effective treatments for cachexia, a profound wasting of fat and muscle that occurs in about half of all cancer patients, increasing their risk of death. Harvard Professor Bruce Spiegelman demonstrated that symptoms of cachexia in mice improved when given an antibody that blocked the effects of a protein secreted by the tumor cells.
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Vasectomy may increase risk of aggressive prostate cancer
Vasectomy is associated with a small increased risk of prostate cancer, and a stronger risk for advanced or lethal prostate cancer, according to a new study from Harvard School of Public Health.
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Obesity risk stronger among siblings
A new study found that two-child families present five times more risk of sibling obesity than single-child homes with an obese parent, which doubles the risk. Obesity risk is even stronger among same-gender siblings.
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New way to regrow human corneas
Harvard-affiliated researchers have identified a way to enhance regrowth of human corneal tissue to restore vision, using a molecule that acts as a marker for hard-to-find limbal stem cells.
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Improving stem cells’ regenerative potential
A team at Harvard Stem Cell Institute recently found that transplanting mesenchymal stem cells along with blood-vessel-forming cells naturally found in circulation improves results. This co-transplantation keeps the mesenchymal stem cells alive longer in mice after engraftment, up to a few weeks compared with hours without co-transplantation.
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The goal: New arms
Will Lautzenheiser, a former Boston University film professor who lost his arms and legs from an infection, has been cleared by the Institutional Review Board at the Harvard-affiliated Brigham and Women’s Hospital for a double arm transplant, a complex procedure requiring 12 to 16 hours of work by a team of surgeons.
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A malignant ‘switch’ in breast cancer
A team of researchers led by David J. Mooney, Robert P. Pinkas Family Professor of Bioengineering at the Harvard School of Engineering and Applied Sciences, has identified a possible mechanism by which normal cells turn malignant in mammary epithelial tissues, those frequently involved in breast cancer.
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A shot against heart attacks?
Harvard Stem Cell Institute scientists collaborating with researchers at the University of Pennsylvania have developed a “genome-editing” approach for permanently reducing cholesterol levels in mice through a single injection, a development with the potential to reduce the risk of heart attacks in humans by 40 to 90 percent.
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Reading shapes
A team of Harvard researchers has demonstrated that a shared developmental mechanism in songbirds is responsible for generating tremendous variability in their beaks, and is also a control on what kind variation can be produced.
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Unmasking a viral invader
A study from Harvard Medical School provides the first comprehensive description of how cytomegalovirus, or CMV, hijacks human cells and suggests entirely new ways to combat the infection.
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Natural hormone molds leaner bodies in mice
A natural hormone that is increased by physical exercise and by exposure to cold improves blood sugar control, suppresses inflammation, and burns fat to mold leaner bodies in mice, report scientists at the Harvard-affiliated Dana-Farber Cancer Institute.
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Bridging science and religion
Divinity School graduate Shelley Brown is combining her love for science and religion to help stitch together two fields that rarely seem to meet.
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A decade of breakthroughs
The Harvard Stem Cell Institute is now 10 years old. What began as an idea embracing cross-disciplinary research quickly became a generator of scientific discoveries.
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House calls, without visits
With a master’s from the School of Public Health, physician Darrell Gray hopes to use telecommunications to extend care to endangered groups in underserved neighborhoods.