Health

A designer drug significantly less toxic than thalidomide has shown impressive activity in prolonging survival of patients with advanced multiple myeloma, report researchers from Dana-Farber Cancer Institute. A multicenter Phase II study of lenalidomide, an altered version of thalidomide, found a response rate of 25 percent among patients with myeloma that had recurred despite multiple prior therapies. Especially important was that long-lasting responses averaging 28 months were seen. When another drug, dexamethasone, was added in patients who were not benefiting from lenalidomide alone, the response rate was improved in a third.

A treatment mainstay for prostate cancer puts men at increased risk for diabetes and cardiovascular disease, according to a large observational study published in the Sept. 20 Journal of Clinical Oncology. “Men with prostate cancer have high five-year survival rates, but they also have higher rates of noncancer mortality than healthy men,” says study author Nancy Keating, assistant professor of health care policy and of medicine at Harvard Medical School (HMS). “This study shows that a common hormonal treatment for prostate cancer may put men at significant risk for other serious diseases. Patients and physicians need to be aware of the elevated risk as they make treatment decisions.”

Findings from a study led by researchers at Dana-Farber Cancer Institute and Children’s Hospital Boston have rewritten science’s understanding of the process of skin tanning – an insight that has…

A treatment mainstay for prostate cancer puts men at increased risk for diabetes and cardiovascular disease, according to a large observational study published in the Sept. 20, 2006, Journal of…

A multi-institutional team of Harvard researchers may have advanced our understanding of physiological aging with a new study in which they greatly reduced the impact of aging on blood stem cells. A report on their findings appears in the latest edition of the journal Nature along with similar but independent findings from research teams at the universities of North Carolina and Michigan.

That intern working on you at the hospital may be so sleep-deprived his or her performance is no better than that of a drunk. That’s one conclusion of a national study by investigators at the Harvard Medical School.

Opening a whole new interface between nanotechnology and neuroscience, scientists at Harvard University have used slender silicon nanowires to detect, stimulate, and inhibit nerve signals along the axons and dendrites of live mammalian neurons.

More than 30 years after the end of the war in Vietnam, the effect of lingering stress on Americans who fought there continues to cause stress among researchers.

Heat waves, like the one that scorched the country in July, are more deadly for some people than for others. Poor blacks and diabetics fare the worst. As you might guess, extreme heat is also hard on the elderly. But as you might not guess, extreme cold has a greater impact.

Experts seeking to explain the amazing diversity of the tropical rain forest have typically done so in two ways, viewing forests as either “evolutionary cradles” that encourage the rapid development…

A study in the June 15, 2006, issue of The New England Journal of Medicine reveals that elevated levels of a molecule called RBP4 (retinol binding protein 4) can foretell…

Harvard Medical School researchers have discovered one way that a hardy disease-causing bacteria could be surviving in the lungs of chronically infected cystic fibrosis patients. “This work is important because…

After more than two years of intensive ethical and scientific review, Harvard Stem Cell Institute (HSCI) researchers at Harvard and Children’s Hospital Boston have been cleared to begin experiments using…

A novel approach to helping smokers kick the habit – a vaccine – will be tested at Massachusetts General Hospital (MGH). The nicotine vaccine NicVax is designed to keep nicotine…

Harvard Medical School announced May 23, 2006 that is has signed a multimillion-dollar license agreement with Merck & Co. Inc. to develop potential therapies for macular degeneration, an eye disease…

Data presented May 19, 2006 at the Heart Rhythm Society’s 27th Annual Scientific Sessions finds that during a 10-year study period more than one in five automatic external defibrillators (AEDs)…

Scientists at Schepens Eye Research Institute, an affiliate of Harvard Medical School, are the first to discover a switch inside blood vessel cells that controls angiogenesis (new blood vessel growth).…

New research by Dana-Farber Cancer Institute scientists suggests that it may one day be possible to immunize healthy individuals against HIV-1, the virus that causes AIDS. In a study published…

Researchers at Harvard Medical School and Children’s Hospital Boston have isolated a molecule that stimulates the regrowth of damaged adult nerve fibers, providing new hope for those suffering from nerve…

Insulin uses two distinct mechanisms to control glucose and the metabolism of blood fats (lipids) in the liver, a new Joslin Diabetes Center-led study has discovered. Failures in each of…

McLean Hospital researchers, along with colleagues from 11 other study sites nationwide, report that the medication naltrexone and up to 20 sessions of alcohol counseling delivered by a behavioral specialist…

Researchers have found that a vaccine for Alzheimer’s disease improves learning and memory deficits in mice. “Our findings show promise for a potentially safer and more effective Alzheimer’s vaccine in…

Researchers from the Divisions of Sleep Medicine at Brigham and Women’s Hospital and Harvard Medical School have found in a double-blind placebo-controlled clinical study that melatonin, taken orally during non-typical…

Massachusetts General Hospital researchers have made important progress in their ongoing effort to regenerate the inner ear’s hair cells, which convert sound vibrations to nerve impulses. In the Proceedings of…

The discovery that bone-marrow derived stem cells can regenerate damaged renal cells in an animal model of Alport syndrome provides a potential new strategy for managing this inherited kidney disease…

Researchers at Harvard Medical School report in the April 23, 2006 issue of Nature that they have identified neurons that encode the values that subjects assign to different items. The…

One of the most common agents in the cytoplasm of the cell, the proteasome, also plays a widespread and critical role in transcription from inside the cell nucleus. Pam Silver,…

For all the tender joints and headaches they relieve and colon cancer they may prevent, the older nonsteroidal anti- inflammatory drugs (NSAIDs) raise another serious health risk. The highly publicized…

Recent advances in chemotherapy have significantly reduced the risk of disease recurrence and death in breast cancer patients whose tumors are not hormone sensitive, according to a study by researchers…

Scientists at Dana-Farber Cancer Institute and collaborators have identified four distinct genetic subtypes of multiple myeloma, a deadly blood cancer, that have different prognoses and might be treated most effectively…