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  • Gene chips aid drug search in rare cancers

    When Kimberly Stegmaier was a pediatric oncology fellow at Dana-Farber and Children’s Hospital Boston six years ago, she says,”I was struck by how poorly our young patients with AML (acute…

  • Seven children doing well with laboratory-grown organs

    Three boys and four girls treated at Children’s Hospital Boston are the first people in the world to receive laboratory-grown organs. The children, aged 4 to 19, received bladders grown…

  • Prayers don’t help heart surgery patients

    Many – if not most people – believe that prayer will help you through a medical crisis such as heart bypass surgery. If a large group of people outside yourself,…

  • X inactivation seen as contact sport

    At an early stage in a female embryo’s development, one of the two X chromosomes in each of its cells becomes inactivated. In two recent papers, the lab of Jeannie…

  • Dominican insects, digitized

    It’s the brilliant colors and otherworldly shapes of the Dominican insects that catch the eye and draw a viewer in. It’s the alien forms magnified for all to see clearly…

  • Getting ACL tears to heal themselves

    Orthopedic surgeon Martha Murray reports that a collagen gel enriched with blood platelets can stimulate natural healing of a partial anterior cruciate ligament (ACL) tear. Murray and colleagues at Harvard-affiliated…

  • Enzyme key in preventing Alzheimer’s onset

    A new discovery has found that Pin1, an enzyme previously shown to prevent the formation of the tangle-like lesions found in the brains of Alzheimer’s disease patients, also plays a…

  • Smoke-free pubs keep Irish eyes smiling

    A survey of air pollution levels in “Irish pubs” around the world has found that indoor air pollution in authentic Irish pubs in Ireland, where a smoke-free law has been…

  • RNA sequence restrains fatal encephalitis

    One short sequence of RNA protected mice from deadly brain inflammation caused by West Nile virus and Japanese encephalitis virus, report Priti Kumar, Manjunath Swamy, and Premlata Shankar. The findings,…

  • Ancient molecules guide new synapse growth

    Recent research has shifted the understanding of a group of specialized molecules in the extracellular matrix, recasting them from scaffolding only to key cue-providers that help guide the formation of…

  • Binge eating disorder may have genetic ties

    Researchers at Harvard-affiliated McLean Hospital have reported that binge eating disorder runs in families, raising the possibility that this condition may have a genetic basis. In the study, published in…

  • Study provides first physiological evidence that insulin is critical for blood vessel formation

    For people with type 2 diabetes, the death rate from a first heart attack is two to three times the death rate of patients without the disease. Similarly, patients with…

  • How gold and other medicinal metals function against rheumatoid arthritis and other autoimmune diseases

    Gold compounds have been used for the treatment of rheumatoid arthritis and other autoimmune diseases for more than 75 years, but until now, how the metals work has been a…

  • The ‘widow effect’ is real

    In findings that highlight how health effects can reverberate through a social network, a researcher at HMS and his colleague report that the serious illness of an elderly spouse increases…

  • DNA copier component found to be real drag

    A study in the Feb. 2, 2006 Nature by Antoine van Oijen’s lab sheds light on a longstanding puzzle in DNA replication: how do the enzymes that copy the two…

  • Protein underlies brain’s response to activity

    Experience helps shape the brain, but how that happens – how synapses are remodeled in response to activity – is one of neurobiology’s biggest mysteries. Though axons and dendrites can…

  • Professor shines light on shadowy condition

    Sandra Fallman avoided mirrors. Walking down sidewalks during dates, she would avoid bright storefront lights, walking near the curb to stay in the shadows. She put 25-watt bulbs in her apartment lights, not to set the mood, but to provide cover. Fallman suffers from a little-known mental condition called body dysmorphic disorder (BDD).

  • Computer use deleted as carpal tunnel syndrome cause

    The popular belief that excessive computer use causes painful carpal tunnel syndrome has been contradicted by experts at Harvard Medical School. According to them, even as much as seven hours a day of tapping on a computer keyboard won’t increase your risk of this disabling disorder.

  • Meditation found to increase brain size

    People who meditate grow bigger brains than those who don’t. Researchers at Harvard, Yale, and the Massachusetts Institute of Technology have found the first evidence that meditation can alter the physical structure of our brains. Brain scans they conducted reveal that experienced meditators boasted increased thickness in parts of the brain that deal with attention and processing sensory input.

  • All placebos not created equal

    While researchers usually use placebos in clinical trials to test the effectiveness of a new treatment, a trial reported in the Feb. 1, 2006 British Medical Journal pitted one placebo against another.

  • Less than half of U.S. health care workers get flu shots

    Steffie Woolhandler, Harvard Medical School associate professor of medicine at Cambridge Health Alliance, and colleagues at the University of California Los Angeles analyzed data from the 2000 National Health Interview…

  • Long-term memory controlled by molecular pathway at synapses

    Even for a fruit fly, learning and memory are important adaptive tools that facilitate survival in the environment. A fly can learn to avoid what may do it harm, such…

  • Alternative screening could cut cervical cancer deaths in poor nations

    In the right hands, a swab of vinegar and a flashlight may detect more cervical cancer around the world than the recommended cytological screening known as a Pap smear. At the right time, a single DNA test for the virus that causes cervical cancer may also outperform repeated Pap smears.

  • Synthetic molecule blocks exit from cell organelle

    The ubiquitous, small GTPases are a family of signal transduction molecules that play crucial roles in numerous biological processes, including cell motility and division. Though scientists have eyed these proteins…

  • RNAi solution knocks down herpes infection

    Ever since RNA interference hit the scene a few years ago as a way to selectively turn off gene expression, researchers have been investigating whether these small but powerful bits…

  • Marine biology mystery solved

    The narwhal has a tooth, or tusk, which emerges from the left side of the upper jaw and is an evolutionary mystery that defies many of the known principles of…

  • Low-dose chemotherapy plus antiangiogenesis drug has activity in advanced breast cancer

    Chemotherapy given in low, frequent doses – a novel strategy called “metronomic” delivery – achieved partial shrinkage of disease in some advanced breast cancer patients when given concurrently with an…

  • Dog genome unleashed

    An international research team led by scientists at the Broad Institute of MIT and Harvard has decoded the DNA of the domestic dog and pinpointed millions of genetic differences that…

  • Teen suicide and antidepressants

    With the recent FDA warning about the use of antidepressants with children and adolescents, doctors and patients are more cautious about treating youth with antidepressants. Parents and doctors are challenged…

  • Lab moves genomic testing into the clinic

    The earliest symptom of the inherited heart condition hypertrophic cardiomyopathy can be sudden death at a tragically young age. Harvard Medical School researchers discovered the first human gene underlying the…